MOLECULAR ARCHITECTURE OF VIRUSES
Molecular Architecture of Viruses
At Ke Lab, we believe in the power of scientific research to make a difference. Our passionate scientists are dedicated to tackling world-class challenges in infectious diseases and cancer. We will build "road maps" for structure-guided vaccine design and therapeutic drug development. Rigorous science will be the epicenter of the Ke Lab.
Research
Cancer-Causing Viruses
Infectious diseases pose serious public health problem globally. We will focus on understanding the molecular architecture of cancer-causing viruses, expanding our knowledge on how these nanomachines function.
Structural Biology
Resolution revolution in cryo-electron microscopy and cryo-electron tomography holds the promise of atomic resolution of protein complexes in situ, including cancer-causing viruses and their interactions with hosts.
Publications
Structures and distributions of SARS-CoV-2 spike proteins on intact virions
Z Ke, J Oton, K Qu, M Cortese, V Zila, L McKeane, T Nakane, J Zivanov, ...
Nature 588 (7838), 498-502 (2020)
Maturation of the matrix and viral membrane of HIV-1
Qu K, Ke Z, Zila V, Anders-Össwein M, Glass B, Mücksch F, Müller R, ...
Science. 373(6555):700-704 (2021).
Promotion of virus assembly and organization by the measles virus matrix protein
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, ...
Nature Communications. 9(1):1736 (2018).
